Molecular Details

DICL_CP_0329944 - N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

Basic Molecular Information

Basic Information

DICL ID

DICL_CP_0329944

PubChem CID

5732

Molecular Formula

C₁₉H₂₁N₃O

Molecular Weight

307.397 g/mol

Synonyms/Alias

[zolpidem; 82626-48-0; Zolpidemum; Zolpidemum [Latin]; Sanval; Zolpidem civ; N;N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1;2-a]pyridin-3-yl]acetamide; UNII-7K383OQI23; DTXSID7045946; CHEBI:1012...[zolpidem; 82626-48-0; Zolpidemum; Zolpidemum [Latin]; Sanval; Zolpidem civ; N;N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1;2-a]pyridin-3-yl]acetamide; UNII-7K383OQI23; DTXSID7045946; CHEBI:10125; N;N;6-Trimethyl-2-(4-methylphenyl)imidazo(1;2-a)pyridine-3-acetamide; 7K383OQI23; CHEMBL911; SL800750; SL 800750; DTXCID5025946; SL 80-0750; Zolpidem (INN); Zolpidemum (Latin); NCGC00095179-01; N;N;6-Trimethyl-2-p-tolylimidazo[1;2-a]pyridine-3-acetamide; ZOLPIDEM [INN]; SL-800750; N;N;6-Trimethyl-2-(4-methylphenyl)imidazo[1;2-a]pyridine-3-acetamide; Imidazo(1;2-a)pyridine-3-acetamide; N;N;6-trimethyl-2-(4-methylphenyl)-; ZOLPIDEM CIV (USP-RS); ZOLPIDEM CIV [USP-RS]; Zolpidem [INN:BAN]; Zolpidem (1.0 mg/mL in Methanol); N;N;6-TRIMETHYL-2-P-TOLYL-IMIDAZO(1;2-A)PYRIDINE-3-ACETAMIDE; [3H]zolpidem; CAS-82626-48-0; Edlular; zolpidem Ambien; N;N-dimethyl-2-(6-methyl-2-(4-methylphenyl)imidazo(1;2-a)pyridin-3-yl)acetamide; Sanval (TN); ZOLPIDEM [MI]; ZOLPIDEM [VANDF]; ZOLPIDEM [WHO-DD]; SCHEMBL80516; BSPBio_002278; BIDD:GT0785; SPECTRUM1505369; GTPL4348; GTPL4362; BDBM26266; N05CF02; HMS1922F22; BCP10205; Tox21_111471; MFCD00153885; STK627113; Zolpidem; >=98% (HPLC); solid; AKOS005560130; Tox21_111471_1; CCG-213403; CS-1468; DB00425; NCGC00095179-02; NCGC00095179-03; NCGC00095179-04; NCGC00095179-05; AS-35386; HY-17441; NS00010401; C07219; D08690; AB00698471-07; AB00698471_09; Q218842; SR-01000763006; SR-01000763006-3; BRD-K44876623-001-01-1; SL 800750; SL-800750; SL800750; N;N;6-Trimethyl-2-(4-methylphenyl)-imidazo[1;2-a]pyridine-3-acetamide; N;N-Dimethyl-2-(6-methyl-2-p-tolyl-imidazo[1;2-a]pyridin-3-yl)-acetamide; 6-methyl-N;N-dimethyl-2-(4-methylphenyl)imidazo[1;2-a]pyridine-3-acetamide; N;N;6-Trimethyl-2-(4-Methyl Phenyl) Imidazo [1;2-alpha] Pyridine-3-Acetamide; N;N-dimethyl-2-[(4S)-6-methyl-2-(4-methylphenyl)imidazo[1;2-a]pyridin-3-yl]acetamide; N;N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1;2-a]pyridin-3-yl]acetamide #; N;N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[3;2-a]pyridin-3-yl]acetamide; N;N;6-Trimethyl-2-(4-methylphenyl)imidazo[1;2-a]pyridine-3-acetamide; N;N;6-Trimethyl-2-p-tolylimidazol[1;2-a]pyridine-3-acetamide; SL 80-0750; SL 800750;]

InChI Key

ZAFYATHCZYHLPB-UHFFFAOYSA-N

InChI

InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,1...

IUPAC Name

N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

CAS Number

82626-48-0

Structure Information

Chemical Structure Visualization

SMILES Notation

2D Molecular Drawing

Carbon (C)

Hydrogen (H)

Oxygen (O)

Nitrogen (N)

Sulfur (S)

SDF

23 25 0 0 0 0 0 0 0 0999 V2000
-6.6684 -0.0889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-5.1980 0.2076 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.7196 1...

Download SDF File (2066 bytes)

Experimental Data

Activity Data

Target Ion Channel

Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2

Uniprot Accession Number

P10064/P0C2W5/P22300

Function

Modulator

Species

Bos taurus (Bovine)

IC₅₀

N/A (Not available)

EC₅₀

N/A (Not available)

K_i

K_i: 383 nM

K_d

N/A (Not available)

Inhibition

N/A (Not available)

Experimental Conditions

pH 7.4

Holding Potential

Not specified

Temperature

4 °C

Test Method

Binding assay ([3H] Ro15-1788)

Test Species

Not specified

Binding Information

Binding Site

Extracellular domain

Binding Site Residue

Benzodiazepine binding site

Disease Information

Related Disease

Not specified

References

DOI

10.1021/jm020944u

URL

N/A (Not available)

PMID

12477354

Patent

N/A (Not available)

Computed Properties

Heavy Atom Count

Rotatable Bonds

logP

3.2488

Complexity

92.5

TPSA (Å²)

37.61

H-Bond Donors

H-Bond Acceptors

Ring Count

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